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The University of Sydney >
Physiology > Allen lab
> Yue-kun Ju
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Dr. Yue-kun Ju
is a senior research fellow of Muscle
Cell Function Laboratory. She was trained as a medical doctor at
The Fourth Military Medical University (FMMU), Xian, China where
she also gained a Master Degree of Medicine.
In 1994 She was
awarded a PhD in Neuroscience from John Curtin School of Medical
Research, Australian National University, in Canberra, for her PhD
thesis titled as “Sodium channels in cardiac myocytes”. Her
supervisors were Prof. Peter Gage, a pioneer of electrophysiology
in Australia, and Dr. David Saint from whom she gained her
patch-clamp skills. She moved to Sydney and join |
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Prof. David
Allen’s laboratory in 1996 and has since that time pursued her
research on the calcium mechanisms that regulate the heart
beating. She is the first author of 20 publications, which have
received over 500 citations.
Her current research
interests include TRPC gene expression and store -operated Ca2+
channels activity in mammalian sino-atrial node and their possible
involvement in cardiac arrhythmia. |
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Using Patch-Calmp
techniques to study ion channels in the heart, and discovered that
persistent Na+ current was increased
by hypoxia.
Ju,
Sain, Gage 1996
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Measuring
intracellualr Ca2+ in pacemaker cells and proposed a new cardiac
pacemaking theory that emphasized the role of the intracellular Ca2+
store and Na+/Ca2+ exchanger current.
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Ca2+
signal was recorded from the center of pacemaker region of mouse
SA node.
(Click on the image to
see the movie) |
Simultaneously
recorded action potentials and intracellular Ca2+signals
from a spontaneously firing toad pacemaker cell
Ju & Allen 1998 |
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With late Prof.
Peter Gage at JCSMR, Canberra 1993
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With Dr
David Sanit at IUPS world congress, Christchurch, 2001
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With Prof.
david Allen, at Rottnest island, WA, 1996 |
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