A Dinudom, P Komwatana, A Srijunbarl, DI Cook
During 1996, work was continued using whole-cell patch-clamp techniques to investigate the mech anisms by which intracellular Cl- and intracellular Na+ inhibit the amiloride-sensitive Na+ channels in mouse mandibular intralobular duct cells. It was found that the Na+ channel activator para-chloromercuriphenyl sulphonate works by preventing the feedback inhibition of Na+ channels by intracellular Na+ and Cl-, whereas the Na+ channel activator benzimidazolylguanidinium works by preventing the feedback inhibition of Na+ channels by intracellular Na+ without having any effect on feedback inhibition by intracellular Cl-.