Research in the laboratory is
related to the cellular processes occurring during development of the embryo
before implantation, including fertilisation, cell division and cell
differentiation. In particular, we are studying the regulation of ion channels
during development and whether they are involved in progression of the cell
cycle. We have recently demonstrated the presence of a novel cell cycle clock
in early mouse embryos that functions independent of the nucleus. We are
currently investigating the intracellular signalling pathways involved in regulation
of this clock and how it is linked to the nuclear cell cycle. In the laboratory
we use techniques such as patch-clamping, molecular biology and methods for
studying protein expression.
Personnel:
Dr Margot Day - Head of
Laboratory
Charmaine Green – Honours student
Sarah Dalati – PhD
student
Sukran Ozsoy – MPhil student
Peggy Chen – MPhil student
Collaborators:
Associate
Professor Chris O'Neill
Human
Reproduction Unit,
Level
11, Kolling Building
Royal North Shore Hospital
St Leonards NSW
2065
Dr Michael Morris
Sesqui Senior
Lecturer in Embryonic Stem Cells
Physiology and Bosch
Institute
Level 11,
Kolling Building
Royal North
Shore Hospital
St Leonards NSW
2065
Australia
Associate Professor
John Rasko and Dr Chuck Bailey
Gene Therapy
Laboratory
Centenary
Institute of Cancer Medicine and Cell Biology
NSW 2042
Australia
CURRENT
RESEARCH:
- Cell cycle regulation of ion channels
in the mouse embryo
- pH regulation in the early mouse
embryo
- Survival factor signaling in the
early embryo
LINKS:
Dr
Margot Day
Sub-Dean
Honours, Sydney Medical Program
Discipline of
Physiology and Bosch Institute,
Rm
232, level 2, Medical Foundation Building (K25)
University
of Sydney
92-94
Parramatta Rd
NSW 2006 AUSTRALIA
Email: margotd@physiol.usyd.edu.au
Phone: +61 2
9036 3312
Fax: +61 2 9036
3316