Cell signalling in the preimplantation embryo

Signalling via changes in intracellular ion concentrations and ion channel activities is critical for many aspects of preimplantation embryo development. For example, the signal that triggers fertilisation of the oocyte is an increase in intracellular calcium. Changes in the pattern of expression of ion channels also occurs during cell division and cell differentiation and we have shown that inhibition of these channels can prevent embryo development. Research in my lab uses electrophysiological techniques (patch-clamping), molecular biology and fluorescent imaging of intracellular ions to study cell signalling in early embryos as well as embryonic stem cells.

Supervisor: Dr Margot Day

Discipline of Physiology and Bosch Institute, School of Medical Sciences

Location: Laboratory of Developmental Physiology

Medical Foundation Building (K25)

Email: margotd@physiol.usyd.edu.au

Phone: 9036 3312