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USyd

Bosch

 

 

 

 

 

 

 

 

 

 

What we do...

In lay terms, research in the Developmental & Cancer Biology Lab focuses on understanding how normal development and cell function is controlled, and then, how this regulation is perturbed to result in cancer (eg. what controls breast development and then if mutated, how does this induce breast cancer and metastasis).

Specifically, research in the lab has focused on transcriptional and cell-matrix 'master' regulators of cell fate (eg. whether or not a cell undergoes proliferation or differentiation) in breast and prostate development and cancer. Using whole genome transcript profiling and subsequent mouse and human cell based models, we have identified several novel regulators of normal breast and prostate development and shown that altering the function of these genes can speed up or slow down cancer progression. We are now exploring the potential diagnoistic and therapeutic potential of these novel targets by exploring their functional mechanism and by expanding our studies to human patient cohorts.

As the genes and developmental pathways we work on control cell fate decisions in multiple systems we will examine the function of these genes in major human diseases such as breast & prostate cancer, bone metastasis, cardiovascular (artherosclerosis), muscle and heart disease.

 

cancer

breast

mammary

PCR

TRAMP